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Baldwin is Medical Director at The Acne Treatment and Research Center in Brooklyn, New York and Clinical Associate Professor of Dermatology at Rutgers Robert Wood Johnson Medical School in New Brunswick, New Jersey

A plausible explanation could be a reorientation of Lys105 towards GS resulting in a decreased stabilization of the active site thiolate as a leaving group

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Response 2 is an undesired effect seen at a dose only slightly greater than those producing the therapeutic effect

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